In this interrupted time series analysis of 80 107 abortions obtained between September 2020 and February 2022, Texas’ law was significantly associated with a decrease in Texas facility–based abortions (incidence rate ratio [IRR], 0.43), an increase in Texas residents obtaining out-of-state abortions (IRR, 5.38), and a decrease in total in-state and out-of-state abortions (IRR, 0.67) in September 2021 compared with August 2021.